Oncoplastic Surgery and Radiation Therapy for Breast Conservation: Early Outcomes
Identifieur interne : 001A29 ( Main/Exploration ); précédent : 001A28; suivant : 001A30Oncoplastic Surgery and Radiation Therapy for Breast Conservation: Early Outcomes
Auteurs : Patrick D. Maguire ; Michael A. Nichols ; Ashley AdamsSource :
- American journal of clinical oncology [ 0277-3732 ] ; 2015.
Abstract
To analyze a multidisciplinary community experience with oncoplastic breast surgery (OBS) and postoperative radiation therapy (RT).
The records of 79 patients with localized breast cancer who underwent OBS + RT were reviewed. OBS included immediate reconstruction and contralateral mammoreduction. All patients had negative surgical margins. Whole breast RT was delivered without boost. A subset of 44 patients agreed to complete a validated quality of life survey pre-RT, post-RT, 6 months after RT, and at final follow-up assessing cosmesis and treatment satisfaction.
Sixty seven patients (85%) were Caucasian. Median age was 62. Median interval between OBS and RT start was 9.6 weeks. Median RT dose was 46 Gy. Fourteen patients (18%) developed surgical toxicities prior to RT. Five patients (6%) developed RT toxicities. Physician rating of cosmesis post-RT was: 3% excellent, 94% good, and 4% fair. Cosmesis was rated as excellent or good by 87% of patients pre-RT, 82% post-RT, 75% at 6 months, and 88% at the final follow-up. Treatment satisfaction was rated as “total” or “somewhat” by 97% of patients pre-RT, 93% post-RT, 75% at 6 months, and 96% at final follow-up. No significant relation was found between patient or treatment-related factors and toxicity. Local control is 100% at median follow-up of 2.9 years.
OBS followed by RT resulted in acceptable toxicity and favorable physician-rated cosmesis in this large community series. Patients’ ratings of cosmesis and treatment satisfaction were initially high, decreasing at 6 months, returning near baseline at final follow-up.
Url:
DOI: 10.1097/COC.0b013e31829d1ef0
PubMed: 23799290
PubMed Central: 3975701
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 003773
- to stream Pmc, to step Curation: 003772
- to stream Pmc, to step Checkpoint: 001014
- to stream Ncbi, to step Merge: 005A69
- to stream Ncbi, to step Curation: 005A69
- to stream Ncbi, to step Checkpoint: 005A69
- to stream Main, to step Merge: 001A32
- to stream Main, to step Curation: 001A29
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Oncoplastic Surgery and Radiation Therapy for Breast Conservation: Early Outcomes</title><author><name sortKey="Maguire, Patrick D" sort="Maguire, Patrick D" uniqKey="Maguire P" first="Patrick D." last="Maguire">Patrick D. Maguire</name></author><author><name sortKey="Nichols, Michael A" sort="Nichols, Michael A" uniqKey="Nichols M" first="Michael A." last="Nichols">Michael A. Nichols</name></author><author><name sortKey="Adams, Ashley" sort="Adams, Ashley" uniqKey="Adams A" first="Ashley" last="Adams">Ashley Adams</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">23799290</idno><idno type="pmc">3975701</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3975701</idno><idno type="RBID">PMC:3975701</idno><idno type="doi">10.1097/COC.0b013e31829d1ef0</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">003773</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">003773</idno><idno type="wicri:Area/Pmc/Curation">003772</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">003772</idno><idno type="wicri:Area/Pmc/Checkpoint">001014</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001014</idno><idno type="wicri:Area/Ncbi/Merge">005A69</idno><idno type="wicri:Area/Ncbi/Curation">005A69</idno><idno type="wicri:Area/Ncbi/Checkpoint">005A69</idno><idno type="wicri:doubleKey">0277-3732:2015:Maguire P:oncoplastic:surgery:and</idno><idno type="wicri:Area/Main/Merge">001A32</idno><idno type="wicri:Area/Main/Curation">001A29</idno><idno type="wicri:Area/Main/Exploration">001A29</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Oncoplastic Surgery and Radiation Therapy for Breast Conservation: Early Outcomes</title><author><name sortKey="Maguire, Patrick D" sort="Maguire, Patrick D" uniqKey="Maguire P" first="Patrick D." last="Maguire">Patrick D. Maguire</name></author><author><name sortKey="Nichols, Michael A" sort="Nichols, Michael A" uniqKey="Nichols M" first="Michael A." last="Nichols">Michael A. Nichols</name></author><author><name sortKey="Adams, Ashley" sort="Adams, Ashley" uniqKey="Adams A" first="Ashley" last="Adams">Ashley Adams</name></author></analytic><series><title level="j">American journal of clinical oncology</title><idno type="ISSN">0277-3732</idno><idno type="eISSN">1537-453X</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Purpose</title><p id="P1">To analyze a multidisciplinary community experience with oncoplastic breast surgery (OBS) and postoperative radiation therapy (RT).</p></sec><sec id="S2"><title>Methods</title><p id="P2">The records of 79 patients with localized breast cancer who underwent OBS + RT were reviewed. OBS included immediate reconstruction and contralateral mammoreduction. All patients had negative surgical margins. Whole breast RT was delivered without boost. A subset of 44 patients agreed to complete a validated quality of life survey pre-RT, post-RT, 6 months after RT, and at final follow-up assessing cosmesis and treatment satisfaction.</p></sec><sec id="S3"><title>Results</title><p id="P3">Sixty seven patients (85%) were Caucasian. Median age was 62. Median interval between OBS and RT start was 9.6 weeks. Median RT dose was 46 Gy. Fourteen patients (18%) developed surgical toxicities prior to RT. Five patients (6%) developed RT toxicities. Physician rating of cosmesis post-RT was: 3% excellent, 94% good, and 4% fair. Cosmesis was rated as excellent or good by 87% of patients pre-RT, 82% post-RT, 75% at 6 months, and 88% at the final follow-up. Treatment satisfaction was rated as “total” or “somewhat” by 97% of patients pre-RT, 93% post-RT, 75% at 6 months, and 96% at final follow-up. No significant relation was found between patient or treatment-related factors and toxicity. Local control is 100% at median follow-up of 2.9 years.</p></sec><sec id="S4"><title>Conclusions</title><p id="P4">OBS followed by RT resulted in acceptable toxicity and favorable physician-rated cosmesis in this large community series. Patients’ ratings of cosmesis and treatment satisfaction were initially high, decreasing at 6 months, returning near baseline at final follow-up.</p></sec></div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Adams, Ashley" sort="Adams, Ashley" uniqKey="Adams A" first="Ashley" last="Adams">Ashley Adams</name><name sortKey="Maguire, Patrick D" sort="Maguire, Patrick D" uniqKey="Maguire P" first="Patrick D." last="Maguire">Patrick D. Maguire</name><name sortKey="Nichols, Michael A" sort="Nichols, Michael A" uniqKey="Nichols M" first="Michael A." last="Nichols">Michael A. Nichols</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001A29 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001A29 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= LymphedemaV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:3975701
|texte= Oncoplastic Surgery and Radiation Therapy for Breast Conservation: Early Outcomes
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:23799290" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a LymphedemaV1
| This area was generated with Dilib version V0.6.31. |  |